Transcription factors with Perturb-seq knockdown data for GNG12-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNG12-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNG12-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:67,539,374–67,540,683 | 292.0 kb | Distal (>10kb) Multiome | 237 | |
| chr1:67,684,310–67,687,012 | 145.6 kb | Distal (>10kb) Multiome | 1205 | |
| chr1:67,688,423–67,689,311 | 143.5 kb | Distal (>10kb) Multiome | 464 | |
| chr1:67,831,832–67,832,498 | at TSS | At TSS | 426 | |
| chr1:67,832,601–67,833,942 | 1.0 kb | Proximal (<10kb) Multiome | 519 | |
| chr1:68,496,039–68,497,758 | 664.9 kb | Distal (>10kb) Multiome HiCAR | 831 |
Genomic view of the GNG12-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.