The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GNAZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNAZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNAZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:23,069,706–23,071,104 | 249 bp | At TSS Multiome | 559 | |
| chr22:23,141,719–23,142,243 | 71.5 kb | Distal (>10kb) Multiome | 454 | |
| chr22:23,145,130–23,145,779 | 74.8 kb | Distal (>10kb) Multiome | 470 | |
| chr22:23,180,182–23,180,918 | 110.2 kb | Distal (>10kb) Multiome | 508 | |
| chr22:23,218,627–23,219,298 | 148.5 kb | Distal (>10kb) Multiome | 428 | |
| chr22:23,230,272–23,230,724 | 160.0 kb | Distal (>10kb) Multiome | 90 | |
| chr22:23,237,087–23,237,780 | 166.8 kb | Distal (>10kb) Multiome | 278 | |
| chr22:23,242,095–23,242,999 | 172.1 kb | Distal (>10kb) Multiome | 214 | |
| chr22:23,367,107–23,367,560 | 296.9 kb | Distal (>10kb) Multiome | 18 |
Genomic view of the GNAZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.