The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for GNAO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNAO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNAO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:56,190,607–56,192,076 | 7 bp | At TSS Multiome | 450 | |
| chr16:56,194,047–56,194,919 | 3.2 kb | Proximal (<10kb) Multiome | 346 | |
| chr16:56,281,237–56,281,831 | 90.3 kb | Distal (>10kb) Multiome | 230 | |
| chr16:56,318,032–56,318,622 | 127.0 kb | Distal (>10kb) Multiome | 401 | |
| chr16:56,356,409–56,357,020 | 165.2 kb | Distal (>10kb) Multiome | 736 | |
| chr16:56,424,368–56,425,945 | 234.1 kb | Distal (>10kb) Multiome | 582 | |
| chr16:56,450,882–56,452,062 | 260.0 kb | Distal (>10kb) Multiome | 828 |
Genomic view of the GNAO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.