This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for GMPPB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GMPPB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GMPPB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,428,857–49,429,869 | 294.5 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,461,484–49,462,134 | 262.2 kb | Distal (>10kb) Multiome | 207 | |
| chr3:49,468,926–49,470,930 | 253.7 kb | Distal (>10kb) Multiome | 919 | |
| chr3:49,539,369–49,540,584 | 184.0 kb | Distal (>10kb) Multiome | 628 | |
| chr3:49,553,618–49,555,244 | 169.5 kb | Distal (>10kb) Multiome | 710 | |
| chr3:49,718,116–49,720,106 | 4.3 kb | Proximal (<10kb) Multiome | 450 | |
| chr3:49,723,361–49,724,517 | 123 bp | At TSS Multiome | 769 | |
| chr3:49,785,831–49,787,202 | 62.7 kb | Distal (>10kb) Multiome | 854 | |
| chr3:49,802,203–49,804,006 | 78.9 kb | Distal (>10kb) Multiome | 733 | |
| chr3:49,856,099–49,857,163 | 132.7 kb | Distal (>10kb) Multiome | 664 | |
| chr3:49,869,590–49,870,249 | 146.0 kb | Distal (>10kb) Multiome | 251 | |
| chr3:49,903,411–49,904,277 | 180.0 kb | Distal (>10kb) Multiome | 415 | |
| chr3:49,929,290–49,930,212 | 205.8 kb | Distal (>10kb) Multiome | 799 | |
| chr3:49,939,635–49,940,747 | 216.1 kb | Distal (>10kb) Multiome | 949 |
Genomic view of the GMPPB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.