This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GMPPA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GMPPA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GMPPA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:219,206,194–219,207,456 | 292.0 kb | Distal (>10kb) Multiome | 861 | |
| chr2:219,217,908–219,219,751 | 279.9 kb | Distal (>10kb) Multiome | 1058 | |
| chr2:219,228,940–219,230,470 | 269.2 kb | Distal (>10kb) Multiome | 914 | |
| chr2:219,245,074–219,245,804 | 253.4 kb | Distal (>10kb) Multiome | 891 | |
| chr2:219,252,908–219,254,656 | 244.9 kb | Distal (>10kb) Multiome | 808 | |
| chr2:219,277,516–219,280,537 | 219.5 kb | Distal (>10kb) Multiome | 1073 | |
| chr2:219,294,524–219,295,391 | 203.9 kb | Distal (>10kb) Multiome | 892 | |
| chr2:219,308,224–219,309,089 | 190.5 kb | Distal (>10kb) Multiome | 742 | |
| chr2:219,386,994–219,389,117 | 110.6 kb | Distal (>10kb) Multiome | 911 | |
| chr2:219,402,761–219,403,203 | 95.9 kb | Distal (>10kb) Multiome | 234 | |
| chr2:219,418,154–219,419,089 | 80.1 kb | Distal (>10kb) Multiome | 147 | |
| chr2:219,433,920–219,435,459 | 64.7 kb | Distal (>10kb) Multiome | 315 | |
| chr2:219,441,439–219,442,557 | 56.9 kb | Distal (>10kb) Multiome | 338 | |
| chr2:219,447,946–219,449,531 | 50.0 kb | Distal (>10kb) Multiome | 244 | |
| chr2:219,476,330–219,477,528 | 22.1 kb | Distal (>10kb) Multiome | 373 | |
| chr2:219,484,139–219,485,299 | 13.9 kb | Distal (>10kb) Multiome HiCAR | 146 | |
| chr2:219,492,631–219,492,889 | 6.0 kb | Proximal (<10kb) | 107 | |
| chr2:219,495,443–219,495,728 | 3.1 kb | Proximal (<10kb) | 290 | |
| chr2:219,496,628–219,497,255 | 1.6 kb | Proximal (<10kb) | 114 | |
| chr2:219,497,658–219,499,313 | 173 bp | At TSS Multiome | 907 | |
| chr2:219,506,707–219,507,641 | 8.2 kb | Proximal (<10kb) Multiome | 205 | |
| chr2:219,509,036–219,510,612 | 11.3 kb | Distal (>10kb) Multiome | 614 | |
| chr2:219,521,083–219,521,760 | 22.5 kb | Distal (>10kb) Multiome HiCAR | 325 | |
| chr2:219,522,621–219,523,337 | 24.2 kb | Distal (>10kb) Multiome HiCAR | 201 | |
| chr2:219,525,558–219,526,393 | 27.2 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr2:219,530,046–219,530,655 | 31.4 kb | Distal (>10kb) Multiome HiCAR | 480 | |
| chr2:219,541,583–219,542,284 | 43.0 kb | Distal (>10kb) Multiome | 764 | |
| chr2:219,542,939–219,544,543 | 45.0 kb | Distal (>10kb) Multiome | 981 | |
| chr2:219,551,360–219,553,449 | 53.7 kb | Distal (>10kb) Multiome | 785 | |
| chr2:219,570,096–219,572,421 | 72.8 kb | Distal (>10kb) Multiome | 948 | |
| chr2:219,597,186–219,598,527 | 99.1 kb | Distal (>10kb) Multiome | 955 | |
| chr2:219,627,103–219,628,325 | 128.9 kb | Distal (>10kb) Multiome | 315 | |
| chr2:219,642,343–219,643,046 | 143.8 kb | Distal (>10kb) Multiome | 686 | |
| chr2:219,684,717–219,685,631 | 186.3 kb | Distal (>10kb) Multiome | 403 |
Genomic view of the GMPPA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.