This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Transcription factors with Perturb-seq knockdown data for GMIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GMIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GMIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:19,384,944–19,386,424 | 258.0 kb | Distal (>10kb) Multiome | 788 | |
| chr19:19,405,072–19,406,890 | 237.9 kb | Distal (>10kb) Multiome | 1014 | |
| chr19:19,461,886–19,462,726 | 181.3 kb | Distal (>10kb) Multiome | 345 | |
| chr19:19,515,735–19,516,510 | 127.4 kb | Distal (>10kb) Multiome HiCAR | 824 | |
| chr19:19,532,119–19,532,674 | 111.2 kb | Distal (>10kb) Multiome HiCAR | 405 | |
| chr19:19,538,087–19,538,726 | 105.3 kb | Distal (>10kb) Multiome HiCAR | 255 | |
| chr19:19,539,681–19,541,846 | 102.2 kb | Distal (>10kb) Multiome HiCAR | 352 | |
| chr19:19,575,151–19,576,000 | 68.0 kb | Distal (>10kb) Multiome | 128 | |
| chr19:19,618,285–19,619,315 | 24.8 kb | Distal (>10kb) Multiome | 414 | |
| chr19:19,627,596–19,629,138 | 15.2 kb | Distal (>10kb) Multiome | 543 | |
| chr19:19,637,337–19,638,344 | 5.9 kb | Proximal (<10kb) Multiome | 153 | |
| chr19:19,643,155–19,644,142 | 154 bp | At TSS Multiome | 595 | |
| chr19:19,663,091–19,664,414 | 20.3 kb | Distal (>10kb) Multiome | 848 | |
| chr19:19,668,196–19,669,404 | 25.1 kb | Distal (>10kb) Multiome | 778 | |
| chr19:19,732,628–19,733,489 | 89.5 kb | Distal (>10kb) Multiome | 701 | |
| chr19:19,775,960–19,777,126 | 133.0 kb | Distal (>10kb) Multiome | 738 | |
| chr19:19,860,773–19,861,447 | 217.6 kb | Distal (>10kb) Multiome | 112 | |
| chr19:19,865,643–19,866,347 | 222.3 kb | Distal (>10kb) Multiome | 685 | |
| chr19:19,866,439–19,867,170 | 223.4 kb | Distal (>10kb) Multiome | 306 | |
| chr19:19,900,670–19,901,891 | 257.3 kb | Distal (>10kb) Multiome | 405 |
Genomic view of the GMIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.