The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GLTP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLTP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLTP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:109,597,611–109,598,240 | 282.6 kb | Distal (>10kb) Multiome | 536 | |
| chr12:109,679,688–109,680,306 | 200.4 kb | Distal (>10kb) Multiome | 69 | |
| chr12:109,697,996–109,698,635 | 182.3 kb | Distal (>10kb) Multiome | 115 | |
| chr12:109,713,288–109,715,156 | 166.8 kb | Distal (>10kb) Multiome | 793 | |
| chr12:109,717,933–109,718,896 | 162.0 kb | Distal (>10kb) Multiome | 199 | |
| chr12:109,737,442–109,738,212 | 142.7 kb | Distal (>10kb) Multiome | 231 | |
| chr12:109,739,699–109,741,057 | 140.4 kb | Distal (>10kb) Multiome | 245 | |
| chr12:109,833,102–109,833,778 | 47.1 kb | Distal (>10kb) Multiome | 217 | |
| chr12:109,845,155–109,845,762 | 35.1 kb | Distal (>10kb) Multiome | 618 | |
| chr12:109,880,019–109,881,173 | 50 bp | At TSS Multiome | 576 | |
| chr12:109,900,106–109,900,747 | 19.8 kb | Distal (>10kb) Multiome | 818 | |
| chr12:109,995,726–109,996,660 | 115.7 kb | Distal (>10kb) Multiome | 811 | |
| chr12:109,998,999–109,999,838 | 118.7 kb | Distal (>10kb) Multiome | 883 | |
| chr12:110,048,083–110,048,797 | 168.0 kb | Distal (>10kb) Multiome | 921 | |
| chr12:110,107,883–110,108,523 | 227.6 kb | Distal (>10kb) Multiome | 171 | |
| chr12:110,123,690–110,124,996 | 243.8 kb | Distal (>10kb) Multiome | 704 |
Genomic view of the GLTP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.