Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GLT8D2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLT8D2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLT8D2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:103,840,241–103,842,325 | 208.8 kb | Distal (>10kb) Multiome | 911 | |
| chr12:103,928,943–103,931,279 | 120.0 kb | Distal (>10kb) Multiome | 1072 | |
| chr12:103,956,327–103,957,900 | 92.9 kb | Distal (>10kb) Multiome | 1090 | |
| chr12:103,965,409–103,966,472 | 84.3 kb | Distal (>10kb) Multiome | 965 | |
| chr12:104,049,717–104,050,283 | 100 bp | At TSS Multiome | 295 | |
| chr12:104,056,123–104,056,488 | 5.9 kb | Proximal (<10kb) | 93 | |
| chr12:104,057,791–104,058,196 | 7.6 kb | Proximal (<10kb) | 134 | |
| chr12:104,063,714–104,065,209 | 14.3 kb | Distal (>10kb) Multiome | 950 | |
| chr12:104,137,119–104,139,117 | 88.1 kb | Distal (>10kb) Multiome | 796 | |
| chr12:104,215,473–104,216,381 | 165.7 kb | Distal (>10kb) Multiome | 514 | |
| chr12:104,286,560–104,287,505 | 236.8 kb | Distal (>10kb) Multiome | 878 | |
| chr12:104,288,643–104,289,175 | 238.7 kb | Distal (>10kb) Multiome | 863 | |
| chr12:104,303,321–104,304,194 | 253.6 kb | Distal (>10kb) Multiome | 316 |
Genomic view of the GLT8D2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.