Predicted to enable molecular adaptor activity. Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization and protein localization involved in acrosome reaction. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in acrosomal vesicle and sperm head-tail coupling apparatus. Predicted to be part of protein complex involved in cell-cell adhesion. Predicted to be active in extracellular space and outer acrosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GLIPR1L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLIPR1L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLIPR1L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:75,329,660–75,330,647 | 4.4 kb | Proximal (<10kb) Multiome | 840 | |
| chr12:75,333,989–75,335,193 | 119 bp | At TSS Multiome | 460 | |
| chr12:75,390,488–75,391,621 | 56.5 kb | Distal (>10kb) Multiome | 653 | |
| chr12:75,484,124–75,485,111 | 150.0 kb | Distal (>10kb) Multiome | 121 | |
| chr12:75,511,106–75,512,100 | 177.0 kb | Distal (>10kb) Multiome | 945 |
Genomic view of the GLIPR1L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.