This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for GKAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GKAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GKAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:83,536,923–83,539,150 | 279.1 kb | Distal (>10kb) Multiome | 773 | |
| chr9:83,622,459–83,623,894 | 194.6 kb | Distal (>10kb) Multiome | 774 | |
| chr9:83,630,907–83,631,624 | 186.5 kb | Distal (>10kb) Multiome | 194 | |
| chr9:83,706,859–83,708,822 | 110.6 kb | Distal (>10kb) Multiome | 1068 | |
| chr9:83,817,135–83,818,401 | 38 bp | At TSS Multiome | 350 | |
| chr9:83,920,675–83,922,066 | 103.6 kb | Distal (>10kb) Multiome | 895 | |
| chr9:83,956,086–83,957,142 | 139.0 kb | Distal (>10kb) Multiome | 869 | |
| chr9:83,979,201–83,981,658 | 162.8 kb | Distal (>10kb) Multiome | 1059 | |
| chr9:85,804,917–85,805,981 | 1987.6 kb | Distal (>10kb) Multiome HiCAR | 304 |
Genomic view of the GKAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.