GIT1

GIT ArfGAP 1

Enables gamma-tubulin binding activity. Involved in positive regulation of microtubule nucleation and regulation of cytokinesis. Located in several cellular components, including focal adhesion; microtubule cytoskeleton; and mitochondrion. Implicated in attention deficit hyperactivity disorder. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC1

Biological processes 65 terms

GABA-ergic synapse (GO:0098982)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)brain development (GO:0007420)brain development (GO:0007420)cell redox homeostasis (GO:0045454)cellular response to epidermal growth factor stimulus (GO:0071364)cellular response to lipopolysaccharide (GO:0071222)centrosome (GO:0005813)centrosome (GO:0005813)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)dendrite (GO:0030425)endosome (GO:0005768)excitatory synapse (GO:0060076)focal adhesion (GO:0005925)focal adhesion (GO:0005925)focal adhesion (GO:0005925)gamma-tubulin binding (GO:0043015)glutamatergic synapse (GO:0098978)growth cone (GO:0030426)identical protein binding (GO:0042802)inhibitory synapse (GO:0060077)intramembranous ossification (GO:0001957)lamellipodium (GO:0030027)maintenance of postsynaptic specialization structure (GO:0098880)membrane (GO:0016020)mitotic spindle pole (GO:0097431)negative regulation of ARF protein signal transduction (GO:0032013)negative regulation of glycolytic process (GO:0045820)negative regulation of inflammatory response to wounding (GO:0106015)negative regulation of interleukin-1 beta production (GO:0032691)neuron projection (GO:0043005)neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0099645)positive regulation of AMPA glutamate receptor clustering (GO:1904719)positive regulation of microtubule nucleation (GO:0090063)positive regulation of receptor catabolic process (GO:2000646)postsynapse (GO:0098794)postsynapse (GO:0098794)postsynapse (GO:0098794)postsynapse (GO:0098794)postsynaptic density (GO:0014069)presynapse (GO:0098793)presynaptic active zone (GO:0048786)protein binding (GO:0005515)protein phosphatase binding (GO:0019903)protein transporter activity (GO:0140318)protein tyrosine kinase binding (GO:1990782)protein-containing complex (GO:0032991)regulation of ARF protein signal transduction (GO:0032012)regulation of ARF protein signal transduction (GO:0032012)regulation of G protein-coupled receptor signaling pathway (GO:0008277)regulation of G protein-coupled receptor signaling pathway (GO:0008277)regulation of G protein-coupled receptor signaling pathway (GO:0008277)regulation of cytokinesis (GO:0032465)scaffold protein binding (GO:0097110)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)spindle pole (GO:0000922)structural constituent of postsynaptic specialization (GO:0098879)synapse (GO:0045202)synapse (GO:0045202)synaptic vesicle recycling (GO:0036465)

Expression (TPM)

TFs regulating GIT1 0 TFs

Transcription factors with Perturb-seq knockdown data for GIT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GIT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GIT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GIT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:29,148,688–29,149,641	440.7 kb	Distal (>10kb) Multiome HiCAR	709
chr17:29,292,464–29,294,599	296.9 kb	Distal (>10kb) Multiome	1029
chr17:29,369,902–29,370,603	219.5 kb	Distal (>10kb) Multiome HiCAR	305
chr17:29,389,919–29,391,325	199.3 kb	Distal (>10kb) Multiome	863
chr17:29,566,006–29,569,574	21.0 kb	Distal (>10kb) Multiome	868
chr17:29,572,746–29,573,303	16.7 kb	Distal (>10kb) Multiome	252
chr17:29,580,387–29,580,617	8.8 kb	Proximal (<10kb)	412
chr17:29,588,688–29,590,312	13 bp	At TSS Multiome	590
chr17:29,590,975–29,592,562	2.1 kb	Proximal (<10kb) Multiome	810
chr17:29,592,842–29,593,189	3.4 kb	Proximal (<10kb)	354
chr17:29,594,208–29,594,416	4.8 kb	Proximal (<10kb)	389
chr17:29,612,906–29,613,942	23.9 kb	Distal (>10kb) Multiome	581
chr17:29,614,997–29,616,357	26.0 kb	Distal (>10kb) Multiome	389
chr17:29,616,988–29,618,466	28.5 kb	Distal (>10kb) Multiome	615
chr17:29,622,374–29,623,287	33.2 kb	Distal (>10kb) Multiome	470
chr17:29,761,028–29,761,644	171.8 kb	Distal (>10kb) Multiome	643

Genome Browser

Genomic view of the GIT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.