This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for GHRHR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GHRHR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GHRHR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:30,933,699–30,933,941 | 4.7 kb | Proximal (<10kb) | 39 | |
| chr7:30,938,297–30,939,075 | at TSS | At TSS | 403 | |
| chr7:30,974,676–30,975,267 | 8.8 kb | Proximal (<10kb) | 244 | |
| chr7:30,977,965–30,978,156 | 5.9 kb | Proximal (<10kb) | 85 | |
| chr7:30,983,471–30,984,223 | at TSS | At TSS | 269 | |
| chr7:30,984,342–30,985,023 | 262 bp | At TSS | 115 |
Genomic view of the GHRHR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.