This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GGT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GGT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GGT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:34,676,509–34,677,593 | 195.8 kb | Distal (>10kb) Multiome | 954 | |
| chr20:34,703,810–34,705,103 | 168.3 kb | Distal (>10kb) Multiome | 903 | |
| chr20:34,708,877–34,710,404 | 163.1 kb | Distal (>10kb) Multiome | 576 | |
| chr20:34,824,452–34,825,860 | 47.4 kb | Distal (>10kb) Multiome | 852 | |
| chr20:34,872,384–34,873,259 | 52 bp | At TSS Multiome | 817 | |
| chr20:34,874,110–34,874,535 | 1.5 kb | Proximal (<10kb) Multiome | 357 | |
| chr20:34,875,878–34,877,081 | 3.6 kb | Proximal (<10kb) Multiome | 852 | |
| chr20:34,955,039–34,956,224 | 83.0 kb | Distal (>10kb) Multiome HiCAR | 1031 | |
| chr20:34,960,537–34,961,054 | 88.1 kb | Distal (>10kb) Multiome HiCAR | 275 | |
| chr20:34,979,568–34,980,289 | 107.1 kb | Distal (>10kb) Multiome HiCAR | 149 | |
| chr20:35,092,320–35,093,398 | 220.0 kb | Distal (>10kb) Multiome | 1139 | |
| chr20:35,146,563–35,147,734 | 274.4 kb | Distal (>10kb) Multiome | 992 | |
| chr20:35,171,731–35,172,358 | 299.2 kb | Distal (>10kb) Multiome | 383 | |
| chr20:35,262,839–35,263,582 | 390.5 kb | Distal (>10kb) Multiome HiCAR | 336 | |
| chr20:35,269,197–35,269,766 | 396.7 kb | Distal (>10kb) Multiome HiCAR | 447 | |
| chr20:35,277,415–35,278,519 | 405.2 kb | Distal (>10kb) Multiome HiCAR | 575 |
Genomic view of the GGT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.