This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for GGPS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GGPS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GGPS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:235,093,150–235,094,131 | 234.8 kb | Distal (>10kb) Multiome | 491 | |
| chr1:235,128,387–235,130,613 | 198.5 kb | Distal (>10kb) Multiome | 1042 | |
| chr1:235,160,743–235,162,007 | 167.3 kb | Distal (>10kb) Multiome | 1015 | |
| chr1:235,304,634–235,305,365 | 23.6 kb | Distal (>10kb) Multiome | 220 | |
| chr1:235,326,947–235,329,481 | 23 bp | At TSS Multiome | 1010 | |
| chr1:235,367,126–235,367,788 | 38.8 kb | Distal (>10kb) Multiome | 851 | |
| chr1:235,503,729–235,505,713 | 176.0 kb | Distal (>10kb) Multiome | 1129 | |
| chr1:235,546,455–235,547,226 | 218.2 kb | Distal (>10kb) Multiome | 80 |
Genomic view of the GGPS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.