This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GGH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GGH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GGH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:61,138,668–61,140,188 | 1899.5 kb | Distal (>10kb) Multiome HiCAR | 676 | |
| chr8:61,713,795–61,715,587 | 1324.2 kb | Distal (>10kb) Multiome HiCAR | 995 | |
| chr8:63,007,532–63,008,488 | 30.9 kb | Distal (>10kb) Multiome | 312 | |
| chr8:63,038,366–63,039,917 | 57 bp | At TSS Multiome | 851 | |
| chr8:63,085,219–63,086,299 | 47.1 kb | Distal (>10kb) Multiome | 381 | |
| chr8:63,167,915–63,169,292 | 129.7 kb | Distal (>10kb) Multiome | 983 |
Genomic view of the GGH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.