This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for GGCX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GGCX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GGCX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:85,285,331–85,285,778 | 275.9 kb | Distal (>10kb) Multiome | 463 | |
| chr2:85,327,503–85,328,538 | 233.4 kb | Distal (>10kb) Multiome | 1009 | |
| chr2:85,354,014–85,355,224 | 206.9 kb | Distal (>10kb) Multiome | 962 | |
| chr2:85,413,587–85,414,333 | 147.7 kb | Distal (>10kb) Multiome | 351 | |
| chr2:85,418,133–85,419,210 | 142.9 kb | Distal (>10kb) Multiome | 885 | |
| chr2:85,420,473–85,421,406 | 140.7 kb | Distal (>10kb) Multiome | 853 | |
| chr2:85,437,445–85,438,463 | 123.7 kb | Distal (>10kb) Multiome | 501 | |
| chr2:85,455,501–85,456,436 | 105.6 kb | Distal (>10kb) Multiome | 268 | |
| chr2:85,468,626–85,469,195 | 92.6 kb | Distal (>10kb) Multiome | 496 | |
| chr2:85,537,623–85,540,152 | 23.8 kb | Distal (>10kb) Multiome | 1210 | |
| chr2:85,546,252–85,547,149 | 15.0 kb | Distal (>10kb) Multiome | 418 | |
| chr2:85,552,128–85,552,355 | 9.1 kb | Proximal (<10kb) | 299 | |
| chr2:85,561,042–85,561,982 | 12 bp | At TSS Multiome | 903 | |
| chr2:85,577,411–85,578,045 | 16.0 kb | Distal (>10kb) Multiome | 505 | |
| chr2:85,578,935–85,580,041 | 18.1 kb | Distal (>10kb) Multiome | 275 | |
| chr2:85,584,249–85,584,853 | 23.1 kb | Distal (>10kb) Multiome | 633 | |
| chr2:85,595,068–85,596,226 | 34.1 kb | Distal (>10kb) Multiome | 804 | |
| chr2:85,601,954–85,603,493 | 41.2 kb | Distal (>10kb) Multiome | 852 | |
| chr2:85,611,558–85,612,589 | 50.5 kb | Distal (>10kb) Multiome | 875 | |
| chr2:85,615,831–85,616,609 | 54.7 kb | Distal (>10kb) Multiome | 898 | |
| chr2:85,678,904–85,679,599 | 117.8 kb | Distal (>10kb) Multiome | 445 | |
| chr2:85,753,145–85,755,032 | 192.3 kb | Distal (>10kb) Multiome | 527 | |
| chr2:85,827,451–85,827,914 | 266.1 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the GGCX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.