This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GGA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GGA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GGA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:23,452,612–23,453,515 | 57.5 kb | Distal (>10kb) Multiome | 1008 | |
| chr16:23,509,880–23,510,853 | 48 bp | At TSS Multiome | 947 | |
| chr16:23,557,038–23,558,356 | 47.0 kb | Distal (>10kb) Multiome | 1119 | |
| chr16:23,595,873–23,596,693 | 85.8 kb | Distal (>10kb) Multiome | 938 | |
| chr16:23,640,088–23,640,480 | 129.7 kb | Distal (>10kb) Multiome | 169 | |
| chr16:23,641,019–23,641,779 | 130.9 kb | Distal (>10kb) Multiome | 1055 | |
| chr16:23,678,415–23,679,119 | 168.3 kb | Distal (>10kb) Multiome | 878 | |
| chr16:23,694,678–23,695,256 | 184.5 kb | Distal (>10kb) Multiome | 456 |
Genomic view of the GGA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.