GFUS

GDP-L-fucose synthase | FX, P35B, SDR4E1, TSTA3

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]

Member of: DE-1

Biological processes 22 terms

'de novo' GDP-L-fucose biosynthetic process (GO:0042351)'de novo' GDP-L-fucose biosynthetic process (GO:0042351)'de novo' GDP-L-fucose biosynthetic process (GO:0042351)GDP-4-dehydro-D-rhamnose reductase activity (GO:0042356)GDP-L-fucose synthase activity (GO:0050577)GDP-L-fucose synthase activity (GO:0050577)GDP-L-fucose synthase activity (GO:0050577)GDP-mannose 3,5-epimerase activity (GO:0047918)GDP-mannose metabolic process (GO:0019673)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)electron transfer activity (GO:0009055)extracellular exosome (GO:0070062)identical protein binding (GO:0042802)isomerase activity (GO:0016853)leukocyte cell-cell adhesion (GO:0007159)nucleotide-sugar biosynthetic process (GO:0009226)oxidoreductase activity (GO:0016491)positive regulation of endothelial cell migration (GO:0010595)positive regulation of endothelial cell-matrix adhesion (GO:1904906)protein binding (GO:0005515)

Expression (TPM)

TFs regulating GFUS 0 TFs

Transcription factors with Perturb-seq knockdown data for GFUS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GFUS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GFUS

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GFUS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:143,334,216–143,335,267	282.7 kb	Distal (>10kb) Multiome	688
chr8:143,368,147–143,369,893	248.8 kb	Distal (>10kb) Multiome	698
chr8:143,407,212–143,408,612	209.4 kb	Distal (>10kb) Multiome	447
chr8:143,428,968–143,431,754	186.6 kb	Distal (>10kb) Multiome	743
chr8:143,540,714–143,542,061	76.0 kb	Distal (>10kb) Multiome	849
chr8:143,553,122–143,554,177	63.8 kb	Distal (>10kb) Multiome	775
chr8:143,558,225–143,558,936	59.0 kb	Distal (>10kb) Multiome	600
chr8:143,567,166–143,570,227	48.4 kb	Distal (>10kb) Multiome	485
chr8:143,571,367–143,572,283	45.8 kb	Distal (>10kb) Multiome	443
chr8:143,577,641–143,578,799	39.2 kb	Distal (>10kb) Multiome	470
chr8:143,596,744–143,599,643	19.9 kb	Distal (>10kb) Multiome	973
chr8:143,608,979–143,610,357	7.8 kb	Proximal (<10kb) Multiome	735
chr8:143,617,068–143,618,380	110 bp	At TSS Multiome	823
chr8:143,635,715–143,636,601	18.5 kb	Distal (>10kb) Multiome	786
chr8:143,684,308–143,684,747	66.9 kb	Distal (>10kb) Multiome	686
chr8:143,716,075–143,716,913	98.8 kb	Distal (>10kb) Multiome	311
chr8:143,733,345–143,734,440	116.3 kb	Distal (>10kb) Multiome HiCAR	663
chr8:143,740,039–143,740,754	123.0 kb	Distal (>10kb) Multiome	308
chr8:143,771,202–143,772,221	154.3 kb	Distal (>10kb) Multiome	405
chr8:143,814,945–143,816,493	198.2 kb	Distal (>10kb) Multiome	893
chr8:143,828,724–143,829,946	211.8 kb	Distal (>10kb) Multiome	933
chr8:143,840,284–143,841,979	223.6 kb	Distal (>10kb) Multiome	551
chr8:143,877,814–143,879,346	261.0 kb	Distal (>10kb) Multiome	444
chr8:143,951,583–143,954,394	334.7 kb	Distal (>10kb) Multiome HiCAR	943

Genome Browser

Genomic view of the GFUS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.