GET3

guided entry of tail-anchored proteins factor 3, ATPase | ARSA-I, TRC40, ASNA1

This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

Member of: DE-1

Biological processes 25 terms

ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)GET complex (GO:0043529)GET complex (GO:0043529)GET complex (GO:0043529)GET complex (GO:0043529)cytoplasm (GO:0005737)cytoplasm (GO:0005737)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)extracellular exosome (GO:0070062)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleoplasm (GO:0005654)protein binding (GO:0005515)protein carrier activity (GO:0140597)protein insertion into ER membrane (GO:0045048)protein insertion into ER membrane (GO:0045048)tail-anchored membrane protein insertion into ER membrane (GO:0071816)tail-anchored membrane protein insertion into ER membrane (GO:0071816)tail-anchored membrane protein insertion into ER membrane (GO:0071816)tail-anchored membrane protein insertion into ER membrane (GO:0071816)

Expression (TPM)

TFs regulating GET3 0 TFs

Transcription factors with Perturb-seq knockdown data for GET3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GET3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GET3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GET3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,440,217–12,441,483	296.1 kb	Distal (>10kb) Multiome	565
chr19:12,484,131–12,485,387	252.3 kb	Distal (>10kb) Multiome	664
chr19:12,495,009–12,495,882	241.7 kb	Distal (>10kb) Multiome	824
chr19:12,550,951–12,551,971	185.6 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	165.5 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	126.2 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	96.9 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	89.4 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	80.0 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	70.4 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	67.6 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	55.7 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	40.5 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	33.9 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	14.7 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	13.1 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	2.4 kb	Proximal (<10kb) Multiome	882
chr19:12,736,470–12,737,780	9 bp	At TSS Multiome	742
chr19:12,757,454–12,758,297	20.7 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	29.1 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	38.3 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	40.8 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	45.6 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	52.9 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	54.4 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	56.6 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	64.8 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	69.4 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	88.7 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	95.5 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	96.8 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	101.3 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	103.7 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	110.6 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	130.5 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	136.2 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	144.3 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	148.2 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	153.9 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	176.2 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	182.2 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	196.6 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	201.3 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	208.8 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	220.1 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	228.3 kb	Distal (>10kb) Multiome	733
chr19:12,983,506–12,983,997	246.5 kb	Distal (>10kb) Multiome	688

Genome Browser

Genomic view of the GET3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.