This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. This protein may have a role in osteoblast differentiation and growth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for GDPD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GDPD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GDPD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:70,133,101–70,133,613 | 289.7 kb | Distal (>10kb) Multiome | 529 | |
| chrX:70,289,676–70,290,592 | 133.2 kb | Distal (>10kb) Multiome | 481 | |
| chrX:70,423,028–70,423,399 | at TSS | At TSS | 126 | |
| chrX:70,433,669–70,435,047 | 11.2 kb | Distal (>10kb) Multiome | 638 | |
| chrX:70,452,116–70,452,807 | 29.1 kb | Distal (>10kb) Multiome | 254 | |
| chrX:70,454,439–70,455,911 | 31.6 kb | Distal (>10kb) Multiome | 546 |
Genomic view of the GDPD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.