GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GCHFR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GCHFR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GCHFR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,470,654–40,471,315 | 293.1 kb | Distal (>10kb) Multiome | 463 | |
| chr15:40,511,458–40,512,083 | 252.3 kb | Distal (>10kb) Multiome | 646 | |
| chr15:40,593,777–40,594,776 | 170.0 kb | Distal (>10kb) Multiome | 899 | |
| chr15:40,694,639–40,695,262 | 69.0 kb | Distal (>10kb) Multiome | 831 | |
| chr15:40,754,834–40,755,729 | 8.7 kb | Proximal (<10kb) Multiome | 816 | |
| chr15:40,763,848–40,764,563 | 33 bp | At TSS Multiome | 799 | |
| chr15:40,765,461–40,765,775 | 1.4 kb | Proximal (<10kb) | 163 | |
| chr15:40,806,990–40,807,956 | 43.5 kb | Distal (>10kb) Multiome | 782 | |
| chr15:40,843,756–40,844,502 | 80.1 kb | Distal (>10kb) Multiome | 364 | |
| chr15:40,873,588–40,874,396 | 109.9 kb | Distal (>10kb) Multiome | 556 | |
| chr15:40,893,927–40,894,547 | 130.3 kb | Distal (>10kb) Multiome | 741 | |
| chr15:40,906,419–40,906,902 | 142.5 kb | Distal (>10kb) Multiome | 630 | |
| chr15:40,941,651–40,942,174 | 177.9 kb | Distal (>10kb) Multiome | 643 | |
| chr15:40,952,899–40,953,683 | 189.3 kb | Distal (>10kb) Multiome | 618 |
Genomic view of the GCHFR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.