This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
Transcription factors with Perturb-seq knockdown data for GAS6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAS6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAS6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:113,584,313–113,585,542 | 279.4 kb | Distal (>10kb) Multiome | 559 | |
| chr13:113,652,944–113,653,751 | 210.7 kb | Distal (>10kb) Multiome | 168 | |
| chr13:113,758,648–113,759,690 | 104.9 kb | Distal (>10kb) Multiome | 428 | |
| chr13:113,860,084–113,861,280 | 3.4 kb | Proximal (<10kb) Multiome | 327 | |
| chr13:113,862,949–113,864,199 | at TSS | At TSS | 374 | |
| chr13:114,131,895–114,133,058 | 268.6 kb | Distal (>10kb) Multiome | 456 | |
| chr13:114,226,784–114,227,286 | 362.9 kb | Distal (>10kb) Multiome HiCAR | 409 | |
| chr13:114,234,692–114,235,425 | 370.9 kb | Distal (>10kb) Multiome HiCAR | 952 |
Genomic view of the GAS6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.