Predicted to act upstream of or within several processes, including cognition; neuron projection extension; and social behavior. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GAREM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAREM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAREM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:25,877,423–25,878,991 | 294.5 kb | Distal (>10kb) Multiome | 984 | |
| chr2:25,912,966–25,913,435 | 259.7 kb | Distal (>10kb) Multiome | 140 | |
| chr2:25,981,827–25,983,286 | 190.5 kb | Distal (>10kb) Multiome | 664 | |
| chr2:26,011,658–26,012,446 | 160.9 kb | Distal (>10kb) Multiome | 485 | |
| chr2:26,033,136–26,034,956 | 139.2 kb | Distal (>10kb) Multiome | 1165 | |
| chr2:26,171,559–26,171,770 | 1.3 kb | Proximal (<10kb) | 224 | |
| chr2:26,172,352–26,174,365 | 60 bp | At TSS Multiome | 420 | |
| chr2:26,178,689–26,179,345 | 6.0 kb | Proximal (<10kb) Multiome | 245 | |
| chr2:26,179,469–26,180,030 | 6.7 kb | Proximal (<10kb) Multiome | 122 | |
| chr2:26,184,159–26,185,510 | 11.8 kb | Distal (>10kb) Multiome | 494 | |
| chr2:26,202,471–26,204,141 | 30.7 kb | Distal (>10kb) Multiome | 38 | |
| chr2:26,244,319–26,245,633 | 71.7 kb | Distal (>10kb) Multiome | 928 | |
| chr2:26,345,352–26,346,859 | 172.9 kb | Distal (>10kb) Multiome HiCAR | 1002 | |
| chr2:26,401,746–26,402,358 | 228.9 kb | Distal (>10kb) Multiome | 231 |
Genomic view of the GAREM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.