Enables GTPase activating protein binding activity and guanyl-nucleotide exchange factor activity. Involved in regulation of protein transport. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GAPVD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAPVD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAPVD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:125,142,890–125,144,084 | 118.2 kb | Distal (>10kb) Multiome | 723 | |
| chr9:125,189,173–125,190,290 | 71.9 kb | Distal (>10kb) Multiome | 830 | |
| chr9:125,199,947–125,201,039 | 61.3 kb | Distal (>10kb) Multiome | 866 | |
| chr9:125,240,934–125,242,115 | 20.3 kb | Distal (>10kb) Multiome | 974 | |
| chr9:125,261,500–125,262,311 | 34 bp | At TSS Multiome | 900 | |
| chr9:125,407,852–125,408,856 | 146.4 kb | Distal (>10kb) Multiome | 615 | |
| chr9:125,515,099–125,515,938 | 253.6 kb | Distal (>10kb) Multiome | 114 |
Genomic view of the GAPVD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.