This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GALNT6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GALNT6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GALNT6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:51,172,263–51,173,510 | 218.6 kb | Distal (>10kb) Multiome | 853 | |
| chr12:51,217,044–51,218,599 | 173.6 kb | Distal (>10kb) Multiome | 687 | |
| chr12:51,238,201–51,239,451 | 152.7 kb | Distal (>10kb) Multiome | 891 | |
| chr12:51,269,409–51,270,816 | 121.7 kb | Distal (>10kb) Multiome | 750 | |
| chr12:51,320,220–51,321,248 | 70.8 kb | Distal (>10kb) Multiome | 315 | |
| chr12:51,371,336–51,371,863 | 20.0 kb | Distal (>10kb) Multiome | 431 | |
| chr12:51,386,423–51,386,739 | 4.6 kb | Proximal (<10kb) | 50 | |
| chr12:51,390,937–51,392,088 | 155 bp | At TSS Multiome | 504 | |
| chr12:51,392,705–51,392,862 | 1.4 kb | Proximal (<10kb) | 134 | |
| chr12:51,395,449–51,396,000 | 4.1 kb | Proximal (<10kb) Multiome | 274 | |
| chr12:51,424,595–51,425,524 | 33.3 kb | Distal (>10kb) Multiome | 499 | |
| chr12:51,590,353–51,591,928 | 199.4 kb | Distal (>10kb) Multiome | 596 |
Genomic view of the GALNT6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.