This gene encodes an enzyme that catalyzes the epimerization of hexose sugars such as glucose and galactose. The encoded protein is expressed in the cytoplasm and has a preference for galactose. The encoded protein may be required for normal galactose metabolism by maintaining the equilibrium of alpha and beta anomers of galactose.[provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for GALM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GALM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GALM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:38,376,242–38,378,169 | 288.6 kb | Distal (>10kb) Multiome | 1082 | |
| chr2:38,432,787–38,433,235 | 233.1 kb | Distal (>10kb) Multiome | 614 | |
| chr2:38,440,476–38,441,570 | 225.2 kb | Distal (>10kb) Multiome | 331 | |
| chr2:38,442,985–38,445,041 | 221.5 kb | Distal (>10kb) Multiome | 354 | |
| chr2:38,535,703–38,536,446 | 129.9 kb | Distal (>10kb) Multiome | 711 | |
| chr2:38,542,771–38,543,473 | 123.0 kb | Distal (>10kb) Multiome | 516 | |
| chr2:38,601,968–38,603,924 | 63.1 kb | Distal (>10kb) Multiome | 1077 | |
| chr2:38,665,660–38,666,774 | 45 bp | At TSS Multiome | 828 | |
| chr2:38,671,367–38,671,769 | 5.3 kb | Proximal (<10kb) | 11 | |
| chr2:38,750,264–38,752,290 | 85.3 kb | Distal (>10kb) Multiome | 1162 | |
| chr2:38,875,424–38,876,417 | 209.8 kb | Distal (>10kb) Multiome | 853 | |
| chr2:38,959,495–38,960,974 | 294.4 kb | Distal (>10kb) Multiome | 291 |
Genomic view of the GALM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.