GALK1
galactokinase 1 | GALK

Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. [provided by RefSeq, Jul 2008]

Member of: DE-1
Biological processes 24 terms
ATP binding (GO:0005524)ATP binding (GO:0005524)carbohydrate phosphorylation (GO:0046835)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)galactokinase activity (GO:0004335)galactokinase activity (GO:0004335)galactokinase activity (GO:0004335)galactokinase activity (GO:0004335)galactokinase activity (GO:0004335)galactose binding (GO:0005534)galactose catabolic process via UDP-galactose, Leloir pathway (GO:0033499)galactose catabolic process via UDP-galactose, Leloir pathway (GO:0033499)galactose metabolic process (GO:0006012)galactose metabolic process (GO:0006012)galactose metabolic process (GO:0006012)kinase activity (GO:0016301)membrane (GO:0016020)membrane (GO:0016020)phosphotransferase activity, alcohol group as acceptor (GO:0016773)protein binding (GO:0005515)
Expression (TPM)
GALK1 — as a Regulated Gene

TFs regulating GALK1 0 TFs

Transcription factors with Perturb-seq knockdown data for GALK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GALK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to GALK1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GALK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:75,481,081–75,481,680 283.8 kb Distal (>10kb) Multiome 64
chr17:75,514,425–75,517,171 249.5 kb Distal (>10kb) Multiome 1158
chr17:75,524,764–75,527,160 239.6 kb Distal (>10kb) Multiome 951
chr17:75,549,465–75,550,388 215.2 kb Distal (>10kb) Multiome 602
chr17:75,587,697–75,590,735 175.8 kb Distal (>10kb) Multiome 744
chr17:75,633,694–75,634,328 131.1 kb Distal (>10kb) Multiome 559
chr17:75,666,763–75,667,767 97.9 kb Distal (>10kb) Multiome 783
chr17:75,720,933–75,721,693 43.8 kb Distal (>10kb) Multiome 509
chr17:75,753,534–75,754,285 11.3 kb Distal (>10kb) Multiome 699
chr17:75,764,621–75,765,674 1 bp At TSS Multiome 769
chr17:75,773,398–75,774,736 8.2 kb Proximal (<10kb) 179
chr17:75,778,786–75,780,191 14.7 kb Distal (>10kb) Multiome 1118
chr17:75,784,060–75,785,640 19.7 kb Distal (>10kb) Multiome 1176
chr17:75,827,420–75,828,293 62.6 kb Distal (>10kb) Multiome 404
chr17:75,830,158–75,830,695 65.2 kb Distal (>10kb) Multiome 190
chr17:75,832,912–75,833,396 68.0 kb Distal (>10kb) Multiome 104
chr17:75,845,103–75,845,662 80.2 kb Distal (>10kb) Multiome 703
chr17:75,854,955–75,856,363 90.4 kb Distal (>10kb) Multiome 1038
chr17:75,877,486–75,878,900 112.9 kb Distal (>10kb) Multiome 884
chr17:75,896,392–75,897,754 131.8 kb Distal (>10kb) Multiome 831
chr17:75,904,371–75,905,532 139.9 kb Distal (>10kb) Multiome 1045
chr17:75,940,734–75,941,471 176.0 kb Distal (>10kb) Multiome 982
chr17:75,978,646–75,980,102 214.2 kb Distal (>10kb) Multiome 1090
chr17:75,983,292–75,984,226 218.7 kb Distal (>10kb) Multiome 236
chr17:76,014,120–76,014,727 249.3 kb Distal (>10kb) Multiome 489
chr17:76,029,331–76,030,158 264.5 kb Distal (>10kb) Multiome 722

Genome Browser

Genomic view of the GALK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:75,471,081 – 76,040,158
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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