This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for GABRG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GABRG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GABRG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:26,767,146–26,767,831 | 204.0 kb | Distal (>10kb) Multiome | 143 | |
| chr15:26,771,278–26,773,906 | 198.2 kb | Distal (>10kb) Multiome | 353 | |
| chr15:26,866,706–26,868,257 | 104.3 kb | Distal (>10kb) Multiome | 172 | |
| chr15:26,967,711–26,968,303 | 2.9 kb | Proximal (<10kb) | 112 | |
| chr15:26,970,760–26,971,806 | 257 bp | At TSS Multiome | 183 | |
| chr15:26,974,213–26,974,616 | 3.0 kb | Proximal (<10kb) | 30 |
Genomic view of the GABRG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.