The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GABRB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GABRB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GABRB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:160,923,664–160,924,371 | 622.6 kb | Distal (>10kb) Multiome HiCAR | 250 | |
| chr5:161,252,448–161,253,506 | 293.6 kb | Distal (>10kb) Multiome | 78 | |
| chr5:161,544,340–161,545,124 | 1.6 kb | Proximal (<10kb) | 271 | |
| chr5:161,545,516–161,549,527 | at TSS | At TSS | 528 | |
| chr5:163,432,842–163,434,227 | 1886.8 kb | Distal (>10kb) Multiome HiCAR | 173 | |
| chr5:163,437,029–163,438,386 | 1890.9 kb | Distal (>10kb) Multiome HiCAR | 946 |
Genomic view of the GABRB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.