Enables transcription cis-regulatory region binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GABPB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GABPB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GABPB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,875,863–150,877,222 | 194.1 kb | Distal (>10kb) Multiome | 912 | |
| chr1:150,925,543–150,926,754 | 144.5 kb | Distal (>10kb) Multiome | 813 | |
| chr1:150,973,876–150,975,458 | 95.9 kb | Distal (>10kb) Multiome | 590 | |
| chr1:150,979,331–150,979,990 | 91.2 kb | Distal (>10kb) Multiome | 562 | |
| chr1:150,981,212–150,981,672 | 89.4 kb | Distal (>10kb) Multiome | 379 | |
| chr1:151,006,389–151,007,024 | 64.0 kb | Distal (>10kb) Multiome | 496 | |
| chr1:151,008,116–151,008,852 | 62.4 kb | Distal (>10kb) Multiome | 763 | |
| chr1:151,047,405–151,048,764 | 22.2 kb | Distal (>10kb) Multiome | 714 | |
| chr1:151,059,187–151,059,842 | 11.2 kb | Distal (>10kb) Multiome | 821 | |
| chr1:151,060,204–151,060,723 | 10.3 kb | Distal (>10kb) Multiome | 346 | |
| chr1:151,070,369–151,071,463 | 326 bp | At TSS Multiome | 835 | |
| chr1:151,131,105–151,132,256 | 60.6 kb | Distal (>10kb) Multiome | 247 | |
| chr1:151,145,115–151,147,333 | 76.0 kb | Distal (>10kb) Multiome | 709 | |
| chr1:151,165,133–151,166,350 | 95.1 kb | Distal (>10kb) Multiome | 940 | |
| chr1:151,189,687–151,190,378 | 119.4 kb | Distal (>10kb) Multiome | 875 | |
| chr1:151,198,185–151,199,073 | 127.7 kb | Distal (>10kb) Multiome | 721 | |
| chr1:151,254,421–151,255,083 | 183.9 kb | Distal (>10kb) Multiome | 770 | |
| chr1:151,281,008–151,283,557 | 210.6 kb | Distal (>10kb) Multiome | 1121 | |
| chr1:151,327,019–151,328,343 | 256.8 kb | Distal (>10kb) Multiome | 719 | |
| chr1:151,346,796–151,347,793 | 276.5 kb | Distal (>10kb) Multiome | 711 |
Genomic view of the GABPB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.