GABARAP
GABA type A receptor-associated protein | ATG8A, MM46

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

Member of: DE-1
Biological processes 45 terms
GABA receptor binding (GO:0050811)GABA receptor binding (GO:0050811)GABA-ergic synapse (GO:0098982)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)actin cytoskeleton (GO:0015629)autophagosome (GO:0005776)autophagosome (GO:0005776)autophagosome assembly (GO:0000045)autophagosome maturation (GO:0097352)autophagosome membrane (GO:0000421)autophagosome membrane (GO:0000421)autophagosome membrane (GO:0000421)autophagosome membrane (GO:0000421)axoneme (GO:0005930)axoneme (GO:0005930)beta-tubulin binding (GO:0048487)cellular response to nitrogen starvation (GO:0006995)chemical synaptic transmission (GO:0007268)cytoplasmic vesicle (GO:0031410)cytoskeleton (GO:0005856)cytosol (GO:0005829)endomembrane system (GO:0012505)extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)lysosome (GO:0005764)microtubule associated complex (GO:0005875)microtubule binding (GO:0008017)mitophagy (GO:0000423)phosphatidylethanolamine binding (GO:0008429)phosphatidylethanolamine binding (GO:0008429)phospholipid binding (GO:0005543)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of protein K48-linked ubiquitination (GO:1902524)protein binding (GO:0005515)protein targeting (GO:0006605)regulation of Rac protein signal transduction (GO:0035020)regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696)reticulophagy (GO:0061709)smooth endoplasmic reticulum (GO:0005790)sperm midpiece (GO:0097225)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)
Expression (TPM)
GABARAP — as a Regulated Gene

TFs regulating GABARAP 0 TFs

Transcription factors with Perturb-seq knockdown data for GABARAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GABARAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to GABARAP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GABARAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:6,995,886–6,996,299 246.5 kb Distal (>10kb) Multiome 124
chr17:7,012,245–7,012,890 229.9 kb Distal (>10kb) Multiome 804
chr17:7,014,335–7,015,213 227.6 kb Distal (>10kb) Multiome 842
chr17:7,021,831–7,024,265 218.6 kb Distal (>10kb) Multiome 614
chr17:7,035,527–7,036,637 206.5 kb Distal (>10kb) Multiome 791
chr17:7,132,532–7,133,109 109.6 kb Distal (>10kb) Multiome 312
chr17:7,177,263–7,177,909 64.9 kb Distal (>10kb) Multiome 453
chr17:7,204,820–7,205,551 37.3 kb Distal (>10kb) Multiome 364
chr17:7,207,943–7,208,476 34.2 kb Distal (>10kb) Multiome 91
chr17:7,213,858–7,216,461 28.0 kb Distal (>10kb) Multiome 737
chr17:7,219,603–7,220,515 22.5 kb Distal (>10kb) Multiome 793
chr17:7,233,847–7,235,210 7.9 kb Proximal (<10kb) Multiome 1020
chr17:7,237,531–7,238,757 4.5 kb Proximal (<10kb) Multiome 502
chr17:7,238,867–7,240,155 2.8 kb Proximal (<10kb) Multiome 783
chr17:7,241,494–7,243,462 606 bp At TSS Multiome 1037
chr17:7,251,263–7,252,962 9.7 kb Proximal (<10kb) Multiome 985
chr17:7,260,746–7,263,748 20.2 kb Distal (>10kb) Multiome 639
chr17:7,280,161–7,282,555 39.2 kb Distal (>10kb) Multiome 841
chr17:7,293,901–7,295,189 52.3 kb Distal (>10kb) Multiome 443
chr17:7,296,224–7,296,683 54.1 kb Distal (>10kb) Multiome 688
chr17:7,306,788–7,309,027 64.9 kb Distal (>10kb) Multiome 896
chr17:7,314,722–7,315,725 72.9 kb Distal (>10kb) Multiome 843
chr17:7,328,881–7,330,972 87.0 kb Distal (>10kb) Multiome 809
chr17:7,349,378–7,350,590 107.8 kb Distal (>10kb) Multiome 414
chr17:7,351,208–7,352,575 109.6 kb Distal (>10kb) Multiome 857
chr17:7,356,082–7,356,523 113.8 kb Distal (>10kb) Multiome 485
chr17:7,383,791–7,384,537 141.8 kb Distal (>10kb) Multiome 218
chr17:7,393,924–7,395,223 152.2 kb Distal (>10kb) Multiome 744
chr17:7,403,290–7,405,695 161.9 kb Distal (>10kb) Multiome 838
chr17:7,435,167–7,437,681 194.7 kb Distal (>10kb) Multiome 828
chr17:7,437,892–7,438,555 195.9 kb Distal (>10kb) Multiome 224
chr17:7,440,048–7,441,211 198.2 kb Distal (>10kb) Multiome 487
chr17:7,444,968–7,446,142 203.1 kb Distal (>10kb) Multiome 632
chr17:7,455,450–7,456,019 213.2 kb Distal (>10kb) Multiome 414
chr17:7,478,839–7,480,126 237.1 kb Distal (>10kb) Multiome 574
chr17:7,483,139–7,485,576 242.0 kb Distal (>10kb) Multiome 1156

Genome Browser

Genomic view of the GABARAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:6,985,886 – 7,495,576
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact