The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for GAB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:143,184,075–143,186,098 | 152.3 kb | Distal (>10kb) Multiome | 949 | |
| chr4:143,308,285–143,308,784 | 28.6 kb | Distal (>10kb) Multiome | 88 | |
| chr4:143,327,879–143,328,606 | 8.6 kb | Proximal (<10kb) | 26 | |
| chr4:143,335,478–143,338,231 | 133 bp | At TSS Multiome | 941 | |
| chr4:143,338,341–143,338,482 | 1.2 kb | Proximal (<10kb) | 22 | |
| chr4:143,513,027–143,514,991 | 176.3 kb | Distal (>10kb) Multiome | 959 | |
| chr4:143,558,240–143,560,120 | 221.9 kb | Distal (>10kb) Multiome | 594 |
Genomic view of the GAB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.