This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for FZD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FZD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FZD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:103,020,472–103,021,647 | 277.9 kb | Distal (>10kb) Multiome | 842 | |
| chr8:103,140,428–103,141,578 | 158.0 kb | Distal (>10kb) Multiome | 259 | |
| chr8:103,298,291–103,299,527 | 35 bp | At TSS Multiome | 649 | |
| chr8:103,370,990–103,372,400 | 72.6 kb | Distal (>10kb) Multiome | 619 | |
| chr8:103,414,336–103,415,724 | 116.3 kb | Distal (>10kb) Multiome | 1010 | |
| chr8:103,498,473–103,502,003 | 202.8 kb | Distal (>10kb) Multiome | 670 |
Genomic view of the FZD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.