The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for FUT9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FUT9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FUT9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:95,802,492–95,803,538 | 212.8 kb | Distal (>10kb) Multiome | 181 | |
| chr6:95,819,126–95,820,464 | 196.1 kb | Distal (>10kb) Multiome | 173 | |
| chr6:96,007,549–96,008,155 | 7.8 kb | Proximal (<10kb) | 94 | |
| chr6:96,010,330–96,010,481 | 5.5 kb | Proximal (<10kb) | 2 | |
| chr6:96,013,592–96,013,815 | 2.2 kb | Proximal (<10kb) | 27 | |
| chr6:96,014,912–96,017,123 | 58 bp | At TSS Multiome | 416 |
Genomic view of the FUT9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.