This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for FUS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FUS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FUS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:30,893,485–30,894,587 | 294.3 kb | Distal (>10kb) Multiome | 950 | |
| chr16:30,895,854–30,897,426 | 291.4 kb | Distal (>10kb) Multiome | 822 | |
| chr16:30,901,969–30,902,794 | 286.1 kb | Distal (>10kb) Multiome | 579 | |
| chr16:30,921,611–30,925,097 | 265.1 kb | Distal (>10kb) Multiome | 1132 | |
| chr16:30,927,705–30,928,596 | 260.3 kb | Distal (>10kb) Multiome | 274 | |
| chr16:30,941,803–30,942,254 | 246.4 kb | Distal (>10kb) Multiome | 507 | |
| chr16:30,947,471–30,950,635 | 238.2 kb | Distal (>10kb) Multiome | 1066 | |
| chr16:30,953,370–30,954,135 | 234.6 kb | Distal (>10kb) Multiome | 499 | |
| chr16:30,956,960–30,958,498 | 230.8 kb | Distal (>10kb) Multiome | 1022 | |
| chr16:30,984,837–30,985,709 | 203.3 kb | Distal (>10kb) Multiome | 787 | |
| chr16:30,996,877–30,998,001 | 191.1 kb | Distal (>10kb) Multiome | 759 | |
| chr16:31,010,379–31,011,032 | 177.8 kb | Distal (>10kb) Multiome | 117 | |
| chr16:31,032,789–31,034,448 | 155.0 kb | Distal (>10kb) Multiome | 1047 | |
| chr16:31,041,996–31,042,665 | 146.1 kb | Distal (>10kb) Multiome | 213 | |
| chr16:31,072,597–31,074,957 | 115.0 kb | Distal (>10kb) Multiome | 1167 | |
| chr16:31,094,132–31,095,139 | 93.6 kb | Distal (>10kb) Multiome | 933 | |
| chr16:31,108,209–31,108,826 | 80.1 kb | Distal (>10kb) Multiome | 733 | |
| chr16:31,117,128–31,118,265 | 70.7 kb | Distal (>10kb) Multiome | 929 | |
| chr16:31,134,682–31,136,040 | 52.8 kb | Distal (>10kb) Multiome | 450 | |
| chr16:31,138,695–31,139,457 | 49.4 kb | Distal (>10kb) Multiome | 413 | |
| chr16:31,141,455–31,143,270 | 46.1 kb | Distal (>10kb) Multiome | 856 | |
| chr16:31,148,229–31,148,775 | 40.0 kb | Distal (>10kb) Multiome | 209 | |
| chr16:31,179,340–31,181,495 | 8.4 kb | Proximal (<10kb) Multiome | 1179 | |
| chr16:31,201,568–31,203,049 | 13.7 kb | Distal (>10kb) Multiome | 507 | |
| chr16:31,214,606–31,216,091 | 26.8 kb | Distal (>10kb) Multiome | 469 | |
| chr16:31,406,131–31,406,947 | 218.0 kb | Distal (>10kb) Multiome HiCAR | 214 | |
| chr16:31,442,550–31,443,636 | 254.6 kb | Distal (>10kb) Multiome | 838 | |
| chr16:31,457,952–31,460,456 | 269.6 kb | Distal (>10kb) Multiome | 1128 | |
| chr16:31,471,780–31,473,168 | 284.4 kb | Distal (>10kb) Multiome | 425 | |
| chr16:31,476,391–31,478,207 | 289.4 kb | Distal (>10kb) Multiome | 750 | |
| chr16:31,487,298–31,488,862 | 299.4 kb | Distal (>10kb) Multiome | 323 |
Genomic view of the FUS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.