This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for FSCN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FSCN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FSCN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:5,296,049–5,297,455 | 296.1 kb | Distal (>10kb) Multiome | 191 | |
| chr7:5,401,296–5,401,948 | 191.2 kb | Distal (>10kb) Multiome | 104 | |
| chr7:5,406,932–5,408,289 | 185.2 kb | Distal (>10kb) Multiome | 281 | |
| chr7:5,412,740–5,413,653 | 179.5 kb | Distal (>10kb) Multiome | 341 | |
| chr7:5,417,700–5,419,525 | 173.9 kb | Distal (>10kb) Multiome | 714 | |
| chr7:5,423,102–5,425,439 | 168.8 kb | Distal (>10kb) Multiome | 834 | |
| chr7:5,426,416–5,429,142 | 165.8 kb | Distal (>10kb) Multiome | 1072 | |
| chr7:5,450,591–5,451,143 | 141.9 kb | Distal (>10kb) Multiome | 306 | |
| chr7:5,486,725–5,487,360 | 105.8 kb | Distal (>10kb) Multiome | 621 | |
| chr7:5,494,650–5,495,099 | 98.0 kb | Distal (>10kb) Multiome | 515 | |
| chr7:5,513,480–5,514,175 | 79.0 kb | Distal (>10kb) Multiome | 815 | |
| chr7:5,524,684–5,527,073 | 66.2 kb | Distal (>10kb) Multiome | 736 | |
| chr7:5,529,088–5,532,313 | 62.9 kb | Distal (>10kb) Multiome | 1081 | |
| chr7:5,554,765–5,555,676 | 37.6 kb | Distal (>10kb) Multiome | 643 | |
| chr7:5,555,801–5,557,053 | 36.2 kb | Distal (>10kb) Multiome | 807 | |
| chr7:5,558,744–5,559,347 | 33.8 kb | Distal (>10kb) Multiome | 525 | |
| chr7:5,562,000–5,564,024 | 30.8 kb | Distal (>10kb) Multiome HiCAR | 859 | |
| chr7:5,569,367–5,570,943 | 22.6 kb | Distal (>10kb) Multiome HiCAR | 694 | |
| chr7:5,574,238–5,575,433 | 17.9 kb | Distal (>10kb) Multiome | 447 | |
| chr7:5,591,580–5,596,769 | 27 bp | At TSS Multiome | 1056 | |
| chr7:5,597,984–5,599,395 | 5.2 kb | Proximal (<10kb) | 379 | |
| chr7:5,606,973–5,608,439 | 14.8 kb | Distal (>10kb) Multiome | 322 | |
| chr7:5,781,073–5,781,919 | 188.8 kb | Distal (>10kb) Multiome | 696 | |
| chr7:5,822,727–5,823,386 | 230.3 kb | Distal (>10kb) Multiome | 650 |
Genomic view of the FSCN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.