Predicted to enable enzyme inhibitor activity. Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be located in centrosome; cytoplasm; and spindle pole. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FRY. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FRY upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FRY, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:31,630,657–31,631,521 | 215.5 kb | Distal (>10kb) Multiome | 121 | |
| chr13:31,846,134–31,847,472 | 16 bp | At TSS Multiome | 499 | |
| chr13:32,025,767–32,026,103 | 5.2 kb | Proximal (<10kb) | 46 | |
| chr13:32,030,849–32,031,840 | 184.7 kb | Distal (>10kb) Multiome | 668 | |
| chr13:32,314,935–32,316,400 | 468.9 kb | Distal (>10kb) Multiome | 896 |
Genomic view of the FRY locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.