Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FOXB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:77,011,944–77,012,817 | 6.8 kb | Proximal (<10kb) | 473 | |
| chr9:77,013,906–77,014,480 | 5.2 kb | Proximal (<10kb) | 51 | |
| chr9:77,014,687–77,015,669 | 4.0 kb | Proximal (<10kb) | 88 | |
| chr9:77,015,830–77,017,016 | 2.6 kb | Proximal (<10kb) | 167 | |
| chr9:77,018,024–77,021,113 | at TSS | At TSS | 262 | |
| chr9:77,022,739–77,023,316 | 3.1 kb | Proximal (<10kb) | 158 |
Genomic view of the FOXB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.