This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for FNIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FNIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FNIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:131,634,659–131,636,194 | 161.6 kb | Distal (>10kb) Multiome | 961 | |
| chr5:131,788,176–131,788,502 | 8.5 kb | Proximal (<10kb) | 5 | |
| chr5:131,796,148–131,797,826 | 157 bp | At TSS Multiome | 1059 | |
| chr5:132,003,192–132,003,913 | 206.5 kb | Distal (>10kb) Multiome HiCAR | 421 | |
| chr5:132,010,633–132,012,365 | 214.7 kb | Distal (>10kb) Multiome HiCAR | 361 |
Genomic view of the FNIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.