Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FNDC10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FNDC10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FNDC10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,307,375–1,310,219 | 291.9 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,324,278–1,325,394 | 275.3 kb | Distal (>10kb) Multiome | 735 | |
| chr1:1,348,716–1,350,027 | 250.6 kb | Distal (>10kb) Multiome | 539 | |
| chr1:1,353,403–1,354,425 | 246.2 kb | Distal (>10kb) Multiome | 276 | |
| chr1:1,374,767–1,375,798 | 224.8 kb | Distal (>10kb) Multiome | 1113 | |
| chr1:1,398,861–1,399,955 | 200.7 kb | Distal (>10kb) Multiome | 879 | |
| chr1:1,406,992–1,407,823 | 192.8 kb | Distal (>10kb) Multiome | 938 | |
| chr1:1,435,318–1,436,066 | 164.5 kb | Distal (>10kb) Multiome | 511 | |
| chr1:1,511,442–1,512,404 | 88.1 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,540,164–1,541,317 | 59.5 kb | Distal (>10kb) Multiome | 195 | |
| chr1:1,573,904–1,575,432 | 25.3 kb | Distal (>10kb) Multiome | 949 | |
| chr1:1,599,098–1,599,831 | 303 bp | At TSS | 334 | |
| chr1:1,599,945–1,600,642 | 42 bp | At TSS Multiome | 307 | |
| chr1:1,615,103–1,616,799 | 15.4 kb | Distal (>10kb) Multiome | 951 | |
| chr1:1,628,379–1,632,529 | 30.0 kb | Distal (>10kb) Multiome | 552 | |
| chr1:1,658,722–1,659,418 | 59.0 kb | Distal (>10kb) Multiome | 602 | |
| chr1:1,724,054–1,724,738 | 124.3 kb | Distal (>10kb) Multiome | 631 | |
| chr1:1,777,637–1,780,173 | 178.7 kb | Distal (>10kb) Multiome | 970 | |
| chr1:1,782,008–1,783,229 | 182.2 kb | Distal (>10kb) Multiome | 590 | |
| chr1:1,890,319–1,891,952 | 291.1 kb | Distal (>10kb) Multiome | 748 |
Genomic view of the FNDC10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.