The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FNBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FNBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FNBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:129,802,988–129,803,555 | 240.0 kb | Distal (>10kb) Multiome | 727 | |
| chr9:129,835,192–129,835,687 | 207.8 kb | Distal (>10kb) Multiome | 701 | |
| chr9:130,042,478–130,043,723 | 115 bp | At TSS Multiome | 793 | |
| chr9:130,171,788–130,172,513 | 129.1 kb | Distal (>10kb) Multiome | 253 | |
| chr9:130,214,219–130,214,715 | 171.4 kb | Distal (>10kb) Multiome | 146 | |
| chr9:130,243,058–130,243,650 | 200.2 kb | Distal (>10kb) Multiome | 380 | |
| chr9:130,265,477–130,266,015 | 222.6 kb | Distal (>10kb) Multiome | 214 |
Genomic view of the FNBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.