This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FMNL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FMNL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FMNL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:152,042,296–152,043,510 | 292.2 kb | Distal (>10kb) Multiome | 242 | |
| chr2:152,055,231–152,056,165 | 279.5 kb | Distal (>10kb) Multiome | 199 | |
| chr2:152,097,676–152,099,753 | 236.2 kb | Distal (>10kb) Multiome | 496 | |
| chr2:152,175,135–152,176,549 | 159.4 kb | Distal (>10kb) Multiome | 1112 | |
| chr2:152,334,897–152,336,898 | 41 bp | At TSS Multiome | 886 | |
| chr2:152,337,002–152,337,159 | 1.8 kb | Proximal (<10kb) | 140 | |
| chr2:152,415,235–152,415,733 | 80.2 kb | Distal (>10kb) Multiome | 256 | |
| chr2:152,452,653–152,454,217 | 118.3 kb | Distal (>10kb) Multiome | 237 |
Genomic view of the FMNL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.