Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FMC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FMC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FMC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:139,090,840–139,094,844 | 246.8 kb | Distal (>10kb) Multiome | 732 | |
| chr7:139,108,547–139,110,090 | 230.8 kb | Distal (>10kb) Multiome | 920 | |
| chr7:139,124,120–139,124,640 | 216.0 kb | Distal (>10kb) Multiome | 304 | |
| chr7:139,133,422–139,134,016 | 206.8 kb | Distal (>10kb) Multiome | 936 | |
| chr7:139,230,473–139,232,505 | 109.4 kb | Distal (>10kb) Multiome | 971 | |
| chr7:139,339,925–139,342,077 | 25 bp | At TSS Multiome | 1259 | |
| chr7:139,359,044–139,360,936 | 19.9 kb | Distal (>10kb) Multiome | 1134 | |
| chr7:139,482,716–139,484,133 | 143.2 kb | Distal (>10kb) Multiome | 464 | |
| chr7:139,499,861–139,500,450 | 159.7 kb | Distal (>10kb) Multiome | 482 | |
| chr7:139,523,378–139,524,503 | 183.4 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the FMC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.