This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Mutations in this gene are a cause of cardiopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2022]
Transcription factors with Perturb-seq knockdown data for FLNC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLNC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLNC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:128,530,813–128,532,054 | 299.2 kb | Distal (>10kb) Multiome | 421 | |
| chr7:128,697,256–128,697,860 | 132.9 kb | Distal (>10kb) Multiome | 373 | |
| chr7:128,738,818–128,739,927 | 91.1 kb | Distal (>10kb) Multiome | 899 | |
| chr7:128,782,847–128,783,828 | 47.0 kb | Distal (>10kb) Multiome HiCAR | 559 | |
| chr7:128,790,457–128,792,157 | 39.0 kb | Distal (>10kb) Multiome | 579 | |
| chr7:128,830,234–128,830,923 | at TSS | At TSS | 356 | |
| chr7:128,831,024–128,832,923 | 1.0 kb | Proximal (<10kb) Multiome | 529 | |
| chr7:128,833,228–128,833,447 | 2.8 kb | Proximal (<10kb) | 178 | |
| chr7:128,842,024–128,842,470 | 11.8 kb | Distal (>10kb) Multiome | 308 | |
| chr7:128,862,244–128,863,913 | 32.4 kb | Distal (>10kb) Multiome | 736 | |
| chr7:128,868,986–128,870,326 | 39.2 kb | Distal (>10kb) Multiome HiCAR | 557 | |
| chr7:128,879,898–128,880,508 | 49.8 kb | Distal (>10kb) Multiome HiCAR | 323 | |
| chr7:128,890,731–128,891,934 | 60.9 kb | Distal (>10kb) Multiome | 231 | |
| chr7:128,911,320–128,912,136 | 81.3 kb | Distal (>10kb) Multiome | 216 | |
| chr7:128,937,568–128,938,346 | 107.5 kb | Distal (>10kb) Multiome | 392 | |
| chr7:129,054,212–129,055,537 | 224.6 kb | Distal (>10kb) Multiome | 1049 |
Genomic view of the FLNC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.