The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
Transcription factors with Perturb-seq knockdown data for FKBP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FKBP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FKBP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:44,896,801–44,898,169 | 237.2 kb | Distal (>10kb) Multiome | 826 | |
| chr14:44,913,447–44,914,054 | 220.7 kb | Distal (>10kb) Multiome | 280 | |
| chr14:44,961,013–44,963,177 | 172.4 kb | Distal (>10kb) Multiome | 890 | |
| chr14:45,083,317–45,084,737 | 50.4 kb | Distal (>10kb) Multiome | 770 | |
| chr14:45,133,924–45,135,140 | 18 bp | At TSS Multiome | 799 | |
| chr14:45,135,659–45,136,491 | 1.5 kb | Proximal (<10kb) Multiome | 641 | |
| chr14:45,252,907–45,254,209 | 118.8 kb | Distal (>10kb) Multiome | 1004 | |
| chr14:45,294,661–45,295,649 | 160.6 kb | Distal (>10kb) Multiome | 171 | |
| chr14:45,393,566–45,394,707 | 259.6 kb | Distal (>10kb) Multiome | 127 |
Genomic view of the FKBP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.