Enables several functions, including AMPylase activity; ATP binding activity; and Hsp70 protein binding activity. Involved in protein adenylylation; regulation of IRE1-mediated unfolded protein response; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FICD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FICD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FICD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:107,685,428–107,686,240 | 829.6 kb | Distal (>10kb) Multiome HiCAR | 930 | |
| chr12:107,903,668–107,904,167 | 611.5 kb | Distal (>10kb) Multiome HiCAR | 469 | |
| chr12:107,912,390–107,913,032 | 602.6 kb | Distal (>10kb) Multiome HiCAR | 361 | |
| chr12:108,129,130–108,130,224 | 385.7 kb | Distal (>10kb) Multiome HiCAR | 423 | |
| chr12:108,316,165–108,316,921 | 198.7 kb | Distal (>10kb) Multiome | 72 | |
| chr12:108,441,995–108,442,516 | 73.1 kb | Distal (>10kb) Multiome | 196 | |
| chr12:108,512,040–108,512,273 | 3.0 kb | Proximal (<10kb) | 209 | |
| chr12:108,514,776–108,515,777 | 151 bp | At TSS Multiome | 685 | |
| chr12:108,560,717–108,561,713 | 45.9 kb | Distal (>10kb) Multiome | 703 | |
| chr12:108,561,872–108,563,300 | 47.2 kb | Distal (>10kb) Multiome | 772 | |
| chr12:108,691,447–108,691,929 | 176.4 kb | Distal (>10kb) Multiome | 745 | |
| chr12:108,730,199–108,732,667 | 216.5 kb | Distal (>10kb) Multiome | 993 | |
| chr12:108,802,154–108,802,651 | 287.0 kb | Distal (>10kb) Multiome | 135 |
Genomic view of the FICD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.