This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for FHL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FHL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FHL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:105,102,893–105,103,524 | 295.9 kb | Distal (>10kb) Multiome | 260 | |
| chr2:105,125,477–105,126,235 | 273.2 kb | Distal (>10kb) Multiome | 89 | |
| chr2:105,139,777–105,140,585 | 258.7 kb | Distal (>10kb) Multiome | 110 | |
| chr2:105,143,409–105,144,624 | 255.1 kb | Distal (>10kb) Multiome | 295 | |
| chr2:105,177,474–105,178,378 | 221.2 kb | Distal (>10kb) Multiome | 179 | |
| chr2:105,237,985–105,238,461 | 160.9 kb | Distal (>10kb) Multiome | 181 | |
| chr2:105,329,281–105,330,301 | 69.3 kb | Distal (>10kb) Multiome | 799 | |
| chr2:105,337,038–105,338,021 | 61.6 kb | Distal (>10kb) Multiome | 812 | |
| chr2:105,398,372–105,399,507 | 113 bp | At TSS Multiome | 708 |
Genomic view of the FHL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.