Predicted to enable actin binding activity and microtubule binding activity. Involved in Golgi ribbon formation; cilium assembly; and stress fiber assembly. Located in cilium and microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FHDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FHDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FHDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:152,679,625–152,680,356 | 256.3 kb | Distal (>10kb) Multiome | 414 | |
| chr4:152,735,720–152,736,367 | 200.3 kb | Distal (>10kb) Multiome | 141 | |
| chr4:152,779,006–152,780,778 | 156.5 kb | Distal (>10kb) Multiome | 903 | |
| chr4:152,808,636–152,809,308 | 127.4 kb | Distal (>10kb) Multiome | 113 | |
| chr4:152,935,209–152,935,467 | 854 bp | At TSS | 161 | |
| chr4:152,935,635–152,938,175 | 102 bp | At TSS Multiome | 620 | |
| chr4:152,956,599–152,958,298 | 21.5 kb | Distal (>10kb) Multiome | 369 | |
| chr4:153,083,338–153,083,974 | 147.3 kb | Distal (>10kb) Multiome | 317 | |
| chr4:153,125,863–153,126,388 | 189.8 kb | Distal (>10kb) Multiome | 64 | |
| chr4:153,152,013–153,153,918 | 217.2 kb | Distal (>10kb) Multiome | 646 | |
| chr4:153,204,222–153,207,340 | 269.5 kb | Distal (>10kb) Multiome | 625 | |
| chr4:153,222,243–153,223,345 | 286.3 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the FHDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.