The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FGF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:122,732,094–122,733,664 | 94.1 kb | Distal (>10kb) Multiome | 777 | |
| chr4:122,783,129–122,784,597 | 43.2 kb | Distal (>10kb) Multiome HiCAR | 393 | |
| chr4:122,826,312–122,828,644 | 984 bp | At TSS Multiome | 764 | |
| chr4:122,834,129–122,834,299 | 7.4 kb | Proximal (<10kb) | 27 | |
| chr4:122,834,678–122,835,270 | 8.0 kb | Proximal (<10kb) | 34 | |
| chr4:122,921,971–122,923,521 | 96.2 kb | Distal (>10kb) Multiome | 914 |
Genomic view of the FGF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.