The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FGF19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGF19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGF19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:69,442,945–69,443,770 | 260.6 kb | Distal (>10kb) Multiome | 754 | |
| chr11:69,636,341–69,637,110 | 67.4 kb | Distal (>10kb) Multiome | 292 | |
| chr11:69,637,726–69,639,648 | 64.9 kb | Distal (>10kb) Multiome | 644 | |
| chr11:69,640,489–69,642,473 | 63.0 kb | Distal (>10kb) Multiome | 770 | |
| chr11:69,674,751–69,675,727 | 28.6 kb | Distal (>10kb) Multiome | 862 | |
| chr11:69,700,636–69,701,130 | 3.2 kb | Proximal (<10kb) Multiome | 508 | |
| chr11:69,703,191–69,705,251 | 242 bp | At TSS Multiome | 446 | |
| chr11:69,705,705–69,706,392 | 1.7 kb | Proximal (<10kb) | 254 | |
| chr11:69,773,877–69,776,365 | 71.5 kb | Distal (>10kb) Multiome | 239 |
Genomic view of the FGF19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.